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Candesartan-d5

CAT: 0804-HY-B0205S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0205S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Candesartan-d5 is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
CAS Number
1189650-58-5
UNSPSC
12352005
Target
Angiotensin Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Purity
95.50
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
[2H]C([2H])([2H])C([2H])([2H])OC1=NC2=CC=CC(C(O)=O)=C2N1CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3
Molecular Formula
C24H15D5N6O3
Molecular Weight
445.48
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362 (9386) :759-66.|[3]Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT (1) receptor antagonist candesartan blocks brain AT (1) receptors. Brain Res. 2000 Jul 14;871 (1) :29-38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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