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Candesartan

CAT: 0804-HY-B0205-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0205-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) [1][2][3].
CAS Number
139481-59-7
Product Name Alternative
CV 11974
UNSPSC
12352005
Hazard Statement
H361
Target
Angiotensin Receptor; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/candesartan.html
Concentration
10mM
Purity
98.50
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)O
Molecular Formula
C24H20N6O3
Molecular Weight
440.45
Precautions
H361
References & Citations
[1]Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362 (9386) :759-66.|[2]Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT (1) receptor antagonist candesartan blocks brain AT (1) receptors. Brain Res. 2000 Jul 14;871 (1) :29-38.|[3]Sonia Villapol, et al. Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012 Dec;37 (13) :2817-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PPARγ

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CatalogName
A5932-5Candesartan

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