Candesartan

• Description :

  Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) [1][2][3].

• Product Name Alternative :

  CV 11974

• UNSPSC :

  12352005

• Hazard Statement :

  H361

• Target :

  Angiotensin Receptor; PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/candesartan.html

• Concentration :

  10mM

• Purity :

  98.50

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)O

• Molecular Formula :

  C24H20N6O3

• Molecular Weight :

  440.45

• Precautions :

  H361

• References & Citations :

  [1]Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362 (9386) :759-66.|[2]Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT (1) receptor antagonist candesartan blocks brain AT (1) receptors. Brain Res. 2000 Jul 14;871 (1) :29-38.|[3]Sonia Villapol, et al. Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012 Dec;37 (13) :2817-29.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  PPARγ

• CAS Number :

  [139481-59-7]