Products for Research Use Only
RegisterLogin

Nicotinamide (Hydrochloride)

CAT: 0804-HY-B0150ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0150ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM) . Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity[1][2][3][4].
CAS Number
25334-23-0
Product Name Alternative
Niacinamide (Hydrochloride) ; Nicotinic acid amide (Hydrochloride)
UNSPSC
12352005
Target
Endogenous Metabolite; HBV; Sirtuin
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nicotinamide-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)N.[H]Cl
Molecular Formula
C6H7ClN2O
Molecular Weight
158.59
References & Citations
[1]Hwang ES, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74 (18) :3347-3362. |[2]Li WY, et al. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Arch Virol. 2016 Mar;161 (3) :621-30. |[3]Zhang Y, et al. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells. Stem Cell Res Ther. 2021 Jun 25;12 (1) :362. |[4]Francesca Scatozza, et al. Nicotinamide inhibits melanoma in vitro and in vivo. J Exp Clin Cancer Res. 2020 Oct 7;39 (1) :211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; SIRT1; SIRT2

Related Products

CatalogName
HY-B0150-01Nicotinamide
HY-B0150S2Nicotinamide-13C6
HY-123033Nicotinamide riboside
HY-B0150S3Nicotinamide-d3
HY-B0150R-01Nicotinamide (Standard)
HY-B0150S-01Nicotinamide-d4
HY-123033C-01Nicotinamide riboside (malate)
HY-116993-01N- (Hydroxymethyl) nicotinamide
HY-123033DNicotinamide riboside (triflate)
HY-123033BNicotinamide riboside (tartrate)

Alternative Products

CatalogName
T72188-01Nicotinamide Hydrochloride
OR73141-015- (Aminomethyl) nicotinamide hydrochloride
T33666-01Nicotinamide, N- (m-difluoromethoxyphenyl) -, hydrochloride
MBS5783208Nicotinamide, N-(m-difluoromethoxyphenyl)-, hydrochloride
OR1045971-012-Chloro-N- (piperidin-3-yl) nicotinamide hydrochloride
OR1050261-012-Chloro-N- (piperidin-4-ylmethyl) nicotinamide hydrochloride
OR1014337-01N-Cyclopropyl-2- (Piperazin-1-yl) Nicotinamide Hydrochloride
OR1054666-01N- (1,3,4-Thiadiazol-2-yl) nicotinamide hydrochloride
sc-354796N- (4-oxo-2-thioxo-1,3-thiazolidin-3-yl) nicotinamide hydrochloride
OR1055032-012- ((7- (3,4-Dimethoxyphenyl) imidazo[1,2-c]pyrimidin-5-yl) amino) nicotinamide hydrochloride

Popular Products