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Nicotinamide (Hydrochloride)

CAT: 0804-HY-B0150ASize: 1 EachDry Ice: NoHazardous: No
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Description
Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM) . Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity[1][2][3][4].
CAS Number
25334-23-0
Product Name Alternative
Niacinamide (Hydrochloride) ; Nicotinic acid amide (Hydrochloride)
UNSPSC
12352005
Target
Endogenous Metabolite; HBV; Sirtuin
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nicotinamide-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)N.[H]Cl
Molecular Formula
C6H7ClN2O
Molecular Weight
158.59
References & Citations
[1]Hwang ES, et al. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017 Sep;74 (18) :3347-3362. |[2]Li WY, et al. The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Arch Virol. 2016 Mar;161 (3) :621-30. |[3]Zhang Y, et al. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells. Stem Cell Res Ther. 2021 Jun 25;12 (1) :362. |[4]Francesca Scatozza, et al. Nicotinamide inhibits melanoma in vitro and in vivo. J Exp Clin Cancer Res. 2020 Oct 7;39 (1) :211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; SIRT1; SIRT2

Chemical Information

3-Pyridinecarboxamide, hydrochloride (1:1)
CAS Number25334-23-0
PubChem CID91408
IUPAC Namepyridine-3-carboxamide;hydrochloride
Molecular FormulaC6H7ClN2O
Molecular Weight158.58
Topological Polar Surface Area56
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count10
Formal Charge0
Complexity114
SMILES
C1=CC(=CN=C1)C(=O)N.Cl
InChI
InChI=1S/C6H6N2O.ClH/c7-6(9)5-2-1-3-8-4-5;/h1-4H,(H2,7,9);1H
InChIKey
OBLVPWTUALCMGD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Pyridinecarboxamide, hydrochloride (1:1)
CAS: 25334-23-0
CID: 91408
Formula: C6H7ClN2O
MW: 158.58
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight158.58
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass158.0246905
Monoisotopic Mass158.0246905
Topological Polar Surface Area56 Ų
Heavy Atom Count10
Formal Charge0
Complexity114
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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