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Nicotinamide riboside

CAT: 0804-HY-123033Size: 1 EachDry Ice: NoHazardous: No
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Description
Nicotinamide riboside, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
CAS Number
1341-23-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Sirtuin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/nicotinamide-riboside.html
Purity
99.99
Solubility
10 mM in DMSO
Smiles
NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O
Molecular Formula
C11H15N2O5
Molecular Weight
255.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Cantó C, et al. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15 (6) :838-47.|[2]Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34 (6) :1581-8.|[3]Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; SIRT1; SIRT3
Citation 01
ACS Appl Mater Interfaces. 2024 May 1;16 (17) :21383-21399.|ACS Appl Mater Interfaces. 2025 Aug 20;17 (33) :47497-47511.|Br J Pharmacol. 2025 Apr 13.|Cell Biosci. 2021 Nov 10;11 (1) :192.|Cells. 2023 Oct 2;12 (19) :2396.|Commun Biol. 2023 Mar 2;6 (1) :235.|FASEB J. 2022 Jul;36 (7) :e22418.|FASEB J. 2024 Apr 15;38 (7) :e23600.|Mol Ther. 2023 Jan 4;31 (1) :193-210.|Redox Biol. 2022 Nov:57:102507.|Res Sq. 2025 Mar 31.|Basic Res Cardiol. 2024 Jun;119 (3) :403-418.|Bone Res. 2025 Jan 26;13 (1) :18.|Curr Issues Mol Biol. 2024 Feb 1;46 (2) :1291-1307.|Exp Eye Res. 2024 Nov:248:110126.|Int J Biol Macromol. 2025 Jul 5;320 (Pt 1) :145750.|Invest Ophthalmol Vis Sci. 2024 Jul 1;65 (8) :1.|J Ginseng Res. 2025 May 10.|Nat Commun. 2023 Jan 16;14 (1) :240.|Toxicol Appl Pharmacol. 2024 Aug 9:117066.

Chemical Information

Nicotinamide Riboside

N-ribosylnicotinamide is a pyridine nucleoside consisting of nicotinamide with a beta-D-ribofuranosyl moiety at the 1-position. It has a role as a geroprotector, a mouse metabolite, a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-glycosylnicotinamide and a pyridine nucleoside.

CAS Number1341-23-7
PubChem CID439924
IUPAC Name1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide
Molecular FormulaC11H15N2O5+
Molecular Weight255.25
XLogP-1.8
Topological Polar Surface Area117
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge1
Complexity314
SMILES
C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
InChI
InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1
InChIKey
JLEBZPBDRKPWTD-TURQNECASA-O
Chemical Structure
2D Structure
2D structure of Nicotinamide Riboside
CAS: 1341-23-7
CID: 439924
Formula: C11H15N2O5+
MW: 255.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight255.25
XLogP3-1.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass255.09809658
Monoisotopic Mass255.09809658
Topological Polar Surface Area117 Ų
Heavy Atom Count18
Formal Charge1
Complexity314
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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