PF-05198007

CAT: 0804-HY-12883A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-12883A-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PF-05198007 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771[1][2].

CAS Number

1235406-19-5

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-05198007.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CNN=C3N)C=C1F)(NC4=CSC=N4)=O

Molecular Formula

C19H12ClF4N5O3S2

Molecular Weight

533.91

References & Citations

[1]Alexandrou AJ, et al. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. PLoS One. 2016 Apr 6;11 (4) :e0152405.|[2]Kushnarev M, et al. Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers. Expert Opin Investig Drugs. 2020 Mar;29 (3) :259-271.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.7

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Alternative Products

Catalog	Name
BA6997-5.1	PF-05198007
MBS579460	PF-03084014 (PF-3084014)
M36412-01	PF-17
M34376-01	PF-184298
M33060-01	PF-04957325
M28021-01	PF-1355
M26783-01	PF-04937319
M26368-01	PF-04885614
M24156-01	PF-9363
M23628-01	PF-06424439

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