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Artemisinin-d3

CAT: 0804-HY-B0094SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0094SSize:1 mg
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Description
Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
CAS Number
176652-07-6
Product Name Alternative
Qinghaosu-d3; NSC 369397-d3
UNSPSC
12352005
Hazard Statement
H242-H400-H410
Target
Akt; Ferroptosis; HCV; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer; Infection; Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C1[C@H](C([2H])([2H])[2H])[C@]2([H])CC[C@@H](C)[C@]3([H])CC[C@@](O4)(C)OO[C@]32[C@]4([H])O1
Molecular Formula
C15H19D3O5
Molecular Weight
285.35
Precautions
P210-P234-P235-P240-P273-P280-P370+P378-P391-P403-P420-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. ; Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.; Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.|[2]Shao-Peng Lin, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.; Zeng Z, |[3]Zhiwen Zeng, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium

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