Artemisinin-13C,d4

Artemisinin-13C,d4

• UNSPSC Description: Artemisinin-13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
• Target Antigen: Akt; Ferroptosis; HCV; Isotope-Labeled Compounds; Parasite
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Apoptosis;Others;PI3K/Akt/mTOR
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Infection; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: O=C(O1)[C@]([2H])(C([2H])([2H])[2H])C2CC[C@@H](C)C3CC[C@@]4(C)OO[C@]32[13C@H]1O4
• Molecular Weight: 287.35
• References & Citations: [1]Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.|[2]Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported