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Dacarbazine (citrate)

CAT: 0804-HY-B0078ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0078ASize:1 Each
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Description
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma[1][2].
CAS Number
64038-56-8
Product Name Alternative
Imidazole Carboxamide (citrate)
UNSPSC
12352005
Target
Antibiotic; Apoptosis
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dacarbazine-citrate.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(/N=N/N(C)C)NC=N1)N.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C12H18N6O8
Molecular Weight
374.31
References & Citations
[1]Abdullah A Al-Badr, et al. Dacarbazine. Profiles Drug Subst Excip Relat Methodol|[2]J M Rojo, et al. Inhibition of T and B lymphoblastic response by mithramycin, dacarbazine, prospidium chloride and peptichemio. Chemotherapy. 1983;29 (5) :345-51.|[3]Int J Cancer, et al. Dacarbazine alone or associated with melanoma-bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice. Int J Cancer. 2020 May 15;146 (10) :2797-2809.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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