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Paclitaxel-d5

CAT: 0804-HY-B0015S-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0015S-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].
CAS Number
1129540-33-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Isotope-Labeled Compounds; Microtubule/Tubulin
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.9
Solubility
10 mM in DMSO|DMF : ≥ 5mg/mL|DMSO : ≥ 5mg/mL|Ethanol : ≥ 1.5mg/mL
Smiles
O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N[C@@H](C2=CC=CC=C2)[C@H](C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@@H]4O)([H])[C@@H]6OC(C7=CC=CC=C7)=O)=O)C(C)(C)[C@@]6(O)C3)=O)O
Molecular Formula
C47H46D5NO14
Molecular Weight
858.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28 (6) :2163-9.|[2]Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24 (1) :27-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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