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Nab-Paclitaxel

CAT: 0804-HY-P99974-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P99974-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel. Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11)[2].
Product Name Alternative
Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007
UNSPSC
12352203
Hazard Statement
H341, H351, H360, H372
Target
Apoptosis; Autophagy; Microtubule/Tubulin
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nab-paclitaxel.html
Purity
99.9
Solubility
H2O : < 0.1 mg/mL (ultrasonic)
Smiles
[Nab-Paclitaxel]
Precautions
H341, H351, H360, H372
References & Citations
[1]Yardley DA. nab-Paclitaxel mechanisms of action and delivery. J Control Release. 2013 Sep 28;170 (3) :365-72.|[2]Yamamoto, Y., et al., (2011) . Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval. OncoTargets and therapy, 4, 123–136.|[3]Zhang, L., Marrano, P., et al., (2013) . Nab-paclitaxel is an active drug in preclinical model of pediatric solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 (21), 5972–5983.
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 4

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