Sulindac (Standard)

• Description:

  Sulindac (Standard) is the analytical standard of Sulindac. This product is intended for research and analytical applications. Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer[1][2].

• Product Name Alternative:

  MK-231 (Standard)

• UNSPSC:

  12352005

• Target:

  NF-κB; PD-1/PD-L1; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Immunology/Inflammation; NF-κB; Others

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sulindac-standard.html

• Smiles:

  O=C(CC(C1=C2C=CC(F)=C1)=C(/C2=C/C3=CC=C(C=C3)S(C)=O)C)O

• Molecular Formula:

  C20H17FO3S

• Molecular Weight:

  356.41

• References & Citations:

  [1]Byong-Ki Cha, et al. Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget. 2016 Aug 30;7 (35) :57213-57227. |[2]Bin Yi, et al. Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy. Mol Cancer Ther. 2021 Jul;20 (7) :1295-1304.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [38194-50-2]