Temocaprilat

CAT: 0804-HY-A0117Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0117Size:1 mg
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Description
Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE) . Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation[1][2][3][4].
CAS Number
[110221-53-9]
Product Name Alternative
Temocapril diacid; Temocaprilate; RS 5139
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/temocaprilat.html
Solubility
10 mM in DMSO
Smiles
OC(CN1C[C@@H](C2=CC=CS2)SC[C@@H](C1=O)N[C@H](C(O)=O)CCC3=CC=CC=C3)=O
Molecular Formula
C21H24N2O5S2
Molecular Weight
448.56
Precautions
H317, H319
References & Citations
[1]Yasunari K, et al. Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S55-60. |[2]Püchler K, et al. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. Br J Clin Pharmacol. 1998 Oct;46 (4) :363-7. |[3]Ito N, et al. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am J Hypertens. 2007 Jul;20 (7) :792-9.|[4]Yang Z H, et al. P-540: Olmesartan and temocaprilat suppress IL-1 [beta]-induced IL-6 expression via a decrease in mRNA stability in vascular smooth muscle cells[J]. American Journal of Hypertension, 2002, 15 (S3) : 228A.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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