Temocapril-d5

• Description:

  Temocapril-d5 is the deuterium labeled Temocapril. Temocapril is an angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases[1][2].

• UNSPSC:

  12352005

• Target:

  Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  C (C (O) =O) N1C[C@] (SC[C@H] (N[C@@H] (CCC2=C (C (=C (C (=C2[2H]) [2H]) [2H]) [2H]) [2H]) C (OCC) =O) C1=O) (C3=CC=CS3) [H]

• Molecular Formula:

  C23H23D5N2O5S2

• Molecular Weight:

  481.64

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Keisuke Ohnishi, et al. Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I–Infused Rats. J Pharmacol Sci. 2013; 122 (2) : 103–108.|[3]Yuma Ishizaki, et al. Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies. Biol Pharm Bull. 2018;41 (5) :697-706.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1356840-03-3