(2S,3R)-Dap-NE (hydrochloride)

• UNSPSC Description:

  (2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

• Target Antigen:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/2s-3r-dap-ne-hydrochloride.html

• Purity:

  98.84

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@@H](C)[C@@H](OC)[C@H]2NCCC2.Cl[H]

• Molecular Weight:

  356.89

• References & Citations:

  [1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44(5): 937-940.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported