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(2S,3R) -LP99

CAT: 0804-HY-116227Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116227Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(2S,3R) -LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R) -LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R) -LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
CAS Number
1808948-28-8
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2s-3r-lp99.html
Purity
99.4
Solubility
10 mM in DMSO
Smiles
CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C
Molecular Formula
C26H30ClN3O4S
Molecular Weight
516.05
References & Citations
[1]Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54 (21) :6217-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD7; BRD9

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