Dehydro Palonosetron (hydrochloride)

• UNSPSC Description:

  Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect[1].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dehydro-palonosetron-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4.[H]Cl

• Molecular Weight:

  330.85

• References & Citations:

  [1]Darmani NA, et al. Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  135729-55-4