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Palonosetron

CAT: 0804-HY-A0018Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0018Size:1 Each
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Description
Palonosetron is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. Palonosetron exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron also possesses antidepressant activity[1][2][3][4].
CAS Number
135729-61-2
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/palonosetron.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5
Molecular Formula
C19H24N2O
Molecular Weight
296.41
Precautions
P264-P270-P330-P501
References & Citations
[1]Barrows, et al. "A screen of FDA-approved drugs for inhibitors of Zika virus infection." Cell host & microbe 20.2 (2016) : 259-270. |[2]Rojas, et al. "Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor." Anesthesia & Analgesia 107.2 (2008) : 469-478. |[3]Wallenborn, et al. "Palonosetron hydrochloride in the prevention and treatment of postoperative nausea and vomiting." Clinical Medicine Insights: Therapeutics 2 (2010) : CMT-S4016.|[4]Sepúlveda-Vildósola, et al. "Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children." Archives of medical research 39.6 (2008) : 601-606. |[5]Sharma J, et al. Evaluation of antidepressant effect of palonosetron in Swiss albino mice[J]. National Journal of Pharmacology and Therapeutics, 2023, 1 (2) : 98-100.|[6]Rojas C, et al. The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J Pharmacol Exp Ther. 2010 Nov;335 (2) :362-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin

Alternative Products

CatalogName
A3697-200Palonosetron
CS-O-42784Hydroxymethyl Palonosetron
MBS3601463-01Palonosetron hydrochloride
RM-P121800-01Palonosetron HCl
GTR19262159-01Dehydro Palonosetron
CS-O-51739Palonosetron D3
CS-O-42783Palonosetron Dihydrxoy
AR-P01115-01Palonosetron Related Compound A (Palonosetron N-Oxide)

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