Desmethyl-QCA276

CAT: 0804-HY-44103Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-44103Size:1 Each
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Description
Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1]. Desmethyl-QCA276 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2126819-55-2]
Product Name Alternative
PROTAC BRD4-binding moiety 4
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-binding-moiety-4-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(C#CC4=CNN=C4)S5)=C5N21
Molecular Formula
C21H17N5OS
Molecular Weight
387.46
References & Citations
[1]Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61 (15) :6685-6704.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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