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Desmethyl Bosentan

CAT: 0804-HY-145516-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-145516-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan.1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
CAS Number
253688-61-8
Product Name Alternative
Ro 47-8634
UNSPSC
12352005
Hazard Statement
H302
Target
Cytochrome P450; Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/desmethyl-bosentan.html
Smiles
O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O
Molecular Formula
C26H27N5O6S
Molecular Weight
537.59
Precautions
P264-P270-P330-P501
References & Citations
[1]van Giersbergen, et al. Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. Br. J. Clin. Pharmacol. 54 (5), 561-562 (2002) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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