Isamoltane (hemifumarate)

CAT: 0804-HY-19578BSize: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19578BSize:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Isamoltane hemifumarate is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity[1].
CAS Number
[874882-92-5]
Product Name Alternative
(±) -Isamoltane (hemifumarate)
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isamoltane-hemifumarate.html
Solubility
10 mM in DMSO
Smiles
OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.O=C(O)/C=C/C(O)=O.[1/2]
Molecular Formula
C16H22N2O2.1/2C4H4O4
Molecular Weight
332.40
References & Citations
[1]Waldmeier PC, et, al. Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun; 337 (6) : 609-20.|[2]Rényi L, et, al. Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343 (1) :1-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3; β adrenergic receptor

Related Products

CatalogName
HY-12177-01Aliskiren (hemifumarate)
HY-103540-01Tabimorelin (hemifumarate)
HY-101327A-01Xamoterol (hemifumarate)
HY-B0076-01Bisoprolol (hemifumarate)
HY-13064A-01Cobimetinib (hemifumarate)
HY-B0031-01Quetiapine (hemifumarate)
HY-12355ASiponimod (hemifumarate)
HY-100490A-01Rilmenidine (hemifumarate)
HY-135827A-01Roginolisib (hemifumarate)
HY-114153A-01PLX5622 (hemifumarate)

Alternative Products

CatalogName
sc-203608Isamoltane hemifumarate
452484-01Isamoltane Hemifumarate discontinued
MBS5810741Isamoltane
MBS3602631-01Aliskiren hemifumarate
MBS3605794-01Xamoterol hemifumarate
M14471-01Formoterol Hemifumarate
0993/10Cyanopindolol hemifumarate
abx282717-01Quetiapine hemifumarate
TRC-R509705-10MGRilmenidine Hemifumarate
MBS5753709PLX5622 hemifumarate

Popular Products