Roginolisib (hemifumarate)

CAT: 0804-HY-135827A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-135827A-01Size:5 mg
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Description
Roginolisib (MSC2360844) hemifumarate is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. Roginolisib hemifumarate shows highly selective against a panel of 278 additional kinases[1].
CAS Number
[1621688-31-0]
Product Name Alternative
MSC2360844 (hemifumarate) ; IOA-244 (hemifumarate)
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/roginolisib-hemifumarate.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NN(C2=CC=C(CN3CCOCC3)C=C2)C(C4=CC=CC(F)=C45)=C1CS5(=O)=O)N6CCOCC6.OC(/C=C/C(O)=O)=O
Molecular Formula
C26H27FN4O5S.1/2C4H4O4
Molecular Weight
584.62
References & Citations
[1]Haselmayer P, et al. Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies. Front Immunol. 2014 May 22;5:233.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PI3Kδ

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