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I-CBP112 (hydrochloride)

CAT: 0804-HY-19541ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19541ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively) . I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9 (+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin[1].
CAS Number
2147701-33-3
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/i-cbp112-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCC(N1CCOC2=C(OC[C@@H]3CN(C)CCC3)C=C(C4=CC=C(OC)C(OC)=C4)C=C2C1)=O.[H]Cl
Molecular Formula
C27H37ClN2O5
Molecular Weight
505.05
References & Citations
[1]Picaud S, et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75 (23) :5106-5119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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