SAH-13C10

• Description :

  SAH-13C10 is the 13C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

• CAS Number :

  [2687960-02-5]

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/sah-13c10.html

• Purity :

  99.90

• Solubility :

  10 mM in DMSO

• Smiles :

  O[13C@H]1[13C@]([H])(N2[13C]3=N[13CH]=N[13C](N)=[13C]3N=[13CH]2)O[13C@H]([13CH2]SCC[C@@H](C(O)=O)N)[13C@H]1O

• Molecular Formula :

  C4 13C10H20N6O5S

• Molecular Weight :

  394.34

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234 (3) :603-8.|[3]Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar21 (3) :290-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported