HSP70-IN-4

HSP70-IN-4

• CAS Number: 1427450-47-2
• UNSPSC Description: HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable[1].
• Target Antigen: HSP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp70-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](C)C=CC=C4)=O.[O-]S(=O)(C5=CC=C(C)C=C5)=O
• Molecular Weight: 553.72
• References & Citations: [1]Miyata Y, et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported