Losartan-d2

CAT: 0804-HY-17512S3Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17512S3Size:1 mg
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Description
Losartan-d2 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
CAS Number
[1030936-22-1]
Product Name Alternative
DuP-753-d2
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
CCCCC1=NC(Cl)=C(C([2H])([2H])O)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
Molecular Formula
C22H21D2ClN6O
Molecular Weight
424.92
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103 (6) : p. 904-12.; Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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