Losartan-d2

• Description :

  Losartan-d2 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

• Product Name Alternative :

  DuP-753-d2

• UNSPSC :

  12352005

• Target :

  Angiotensin Receptor

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCC1=NC(Cl)=C(C([2H])([2H])O)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2

• Molecular Formula :

  C22H21D2ClN6O

• Molecular Weight :

  424.92

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103 (6) : p. 904-12.; Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1030936-22-1]