Timolol (hemimaleate)

CAT: 0804-HY-17494BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-17494BSize:1 Each
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Description
Timolol ((S) -L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].
CAS Number
[33305-95-2]
Product Name Alternative
(S) -L-714,465 (hemimaleate) ; MK 950 (hemimaleate)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/timolol-hemimaleate.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C\C(O)=O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N2CCOCC2.[1/2]
Molecular Formula
C13H24N4O3S.1/2C4H4O4
Molecular Weight
374.45
References & Citations
[1]James Barnes; Majid Moshirfar. Timolol.|[2]E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22 (1) :152.|[3]Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46 (5) :377-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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