Timolol

• Description :

  Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

• Product Name Alternative :

  (S) -L-714,465; MK 950 (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Cardiovascular Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/timolol.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C

• Molecular Formula :

  C13H24N4O3S

• Molecular Weight :

  316.42

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]James Barnes; Majid Moshirfar. Timolol.|[2]E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22 (1) :152.|[3]Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46 (5) :377-87.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β adrenergic receptor

• Citation 01 :

  Patent. US20230090708A1.|Redox Biol. 2024 Dec 21:79:103481.|Adv Mater. 2025 Jan 6:e2419306.|Mater Today Bio. 2025 Apr 12:32:101752.|Protein Cell. 2019 Mar;10 (3) :178-195.

• CAS Number :

  [26839-75-8]