Cortisone-13C3

• Description :

  Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid) . Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

• UNSPSC :

  12352211

• Target :

  Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Endocrinology; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cortisone-13c3.html

• Concentration :

  275.16 μM * 1 mL in Methanol

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=[13CH][13C]([13CH2]C[C@]4(C)[C@@]3([H])C2=O)=O

• Molecular Formula :

  C18 13C3H28O5

• Molecular Weight :

  363.42

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1 (12) :2109-15.|[3]McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3 (2) :159-76.|[4]Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41 (8) :1299-1302.|[5]Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115 (5) :1370-4.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2350278-95-2]