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Cortisone-13C3

CAT: 0804-HY-17461SSize: 100 μg (275.16 μM x 1 mL in Methanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-17461SSize:100 μg (275.16 μM x 1 mL in Methanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid) . Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
CAS Number
2350278-95-2
UNSPSC
12352211
Target
Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cortisone-13c3.html
Concentration
275.16 μM * 1 mL in Methanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=[13CH][13C]([13CH2]C[C@]4(C)[C@@]3([H])C2=O)=O
Molecular Formula
C18 13C3H28O5
Molecular Weight
363.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1 (12) :2109-15.|[3]McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3 (2) :159-76.|[4]Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41 (8) :1299-1302.|[5]Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115 (5) :1370-4.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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