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21-Deoxy cortisone

CAT: 0804-HY-W741510-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W741510-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1, but can also be produced by oxidation of 21-deoxycortisone by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase, and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia.
CAS Number
1882-82-2
Product Name Alternative
21-Desoxycortisone; NSC 38722
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/21-deoxy-cortisone.html
Smiles
O=C([C@@]1([C@]2(CC([C@]3([C@@]([H])(CCC4=CC(CC[C@@]43C)=O)[C@@]2(CC1)[H])[H])=O)C)O)C
Molecular Formula
C21H28O4
Molecular Weight
344.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Saisho, et al. Changes of several adrenal Δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm. Res. 33 (1), 27-34 (1990) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

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271449-0121-Deoxy cortisone
sc-234419Cortisone 21-acetate
AR-C03584-01Cortisone 21-Valerate
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