Cortisone

• Description:

  Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid) . Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

• Product Name Alternative:

  17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; Glucocorticoid Receptor

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Endocrinology; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Cortisone.html

• Concentration:

  10mM

• Purity:

  99.48

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])C2=O)=O

• Molecular Formula:

  C21H28O5

• Molecular Weight:

  360.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1 (12) :2109-15.|[2]McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3 (2) :159-76.|[3]Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41 (8) :1299-1302.|[4]Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115 (5) :1370-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [53-06-5]