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(R) -Clevidipine-13C, d3

CAT: 0804-HY-17436S3Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17436S3Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Clevidipine-13C, d3 is the deuterium and 13C labeled Clevidipine[1]. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V (H) = -40 mV) under development for treatment of perioperative hypertension[2].
UNSPSC
12352005
Target
Calcium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C)=C(C(OCOC(CCC)=O)=O)[C@@H]1C2=CC=CC(Cl)=C2Cl)O[13C]([2H])([2H])[2H]
Molecular Formula
C20 13CH20D3Cl2NO6
Molecular Weight
460.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Yi X, Vivien B, Lynch C 3rd. Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pigventricular myocytes.; Huraux C, Makita T, Szlam F, The vasodilator effects of clevidipine on human internal mammary artery. Anesth Analg. 1997 Nov;85 (5) :1000-4.; Ericsson H, et al. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man. Eur J Pharm Sci. 1999 Apr;8 (1) :29-37.; Ericsson H, et al. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs. Drug Metab Dispos. 1999 May;27 (5) :558-64.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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