Erythromycin-13C, d3

• Description:

  Erythromycin-13C, d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Infection

• Purity:

  99.50

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@H] ([C@@H] ([C@H] (C (O[C@@H] ([C@@] (O) ([C@@H] ([C@H] (C ([C@@H] (C[C@]1 (O) C) C) =O) C) O) C) CC) =O) C) O[C@H]2C[C@] (C) ([C@H] ([C@@H] (O2) C) O) OC) [C@H]1O[C@H]3[C@@H] ([C@H] (C[C@H] (O3) C) N (C) [13C] ([2H]) ([2H]) [2H]) O

• Molecular Formula:

  C36 13CH64D3NO13

• Molecular Weight:

  737.94

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66 (1) :79-89.|[3]Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006 Dec;100 (3) :185-91. Epub 2006 Nov 28.|[4]K Hamada, et al. Antitumor Effect of Erythromycin in Mice. Chemotherapy

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  Macrolide

• CAS Number:

  2378755-50-9