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Penciclovir-d4

CAT: 0804-HY-17424SSize: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-17424SSize:500 µg
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Description
Penciclovir-d4 is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].
CAS Number
[1020719-72-5]
Product Name Alternative
BRL 39123-d4; VSA 671-d4
UNSPSC
12352005
Target
HSV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Purity
97.0
Solubility
10 mM in DMSO|DMSO : 25mg/mL (ultrasonic) |H2O : 2mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OCC(CO)C([2H])([2H])C([2H])([2H])N1C2=C(C(N=C(N2)N)=O)N=C1
Molecular Formula
C10H11D4N5O3
Molecular Weight
257.28
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Piret J, et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55 (2) :459-72.|[3]Xiong Z, et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living micewith mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med. 2006 Jan;47 (1) :130-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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