Temozolomide-d3

• Description:

  Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H340, H350, H360, H412

• Target:

  Apoptosis; Autophagy; DNA Alkylator/Crosslinker

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.87

• Solubility:

  10 mM in DMSO|DMF : ≥ 5mg/mL|DMSO : ≥ 5mg/mL

• Smiles:

  O=C (N1C=N2) N (N=NC1=C2C (N) =O) C ([2H]) ([2H]) [2H]

• Molecular Formula:

  C6H3D3N6O2

• Molecular Weight:

  197.17

• Precautions:

  H302, H340, H350, H360, H412

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tentori L, et al. Combined treatment with temozolomide and poly (ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99 (6) :2241-4.|[3]Perazzoli G, et al. Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression. PLoS One. 2015 Oct 8;10 (10) :e0140131.|[4]Mathieu V, et al. Combining Anti-Human VEGF with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. Neoplasia. 2008 Dec;10 (12) :1383-92.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  208107-14-6