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Temozolomide-d3

CAT: 0804-HY-17364SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17364SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].
CAS Number
208107-14-6
UNSPSC
12352005
Hazard Statement
H302, H340, H350, H360, H412
Target
Apoptosis; Autophagy; DNA Alkylator/Crosslinker
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.87
Solubility
10 mM in DMSO|DMF : ≥ 5mg/mL|DMSO : ≥ 5mg/mL
Smiles
O=C(N1C=N2)N(N=NC1=C2C(N)=O)C([2H])([2H])[2H]
Molecular Formula
C6H3D3N6O2
Molecular Weight
197.17
Precautions
H302, H340, H350, H360, H412
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tentori L, et al. Combined treatment with temozolomide and poly (ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99 (6) :2241-4.|[3]Perazzoli G, et al. Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression. PLoS One. 2015 Oct 8;10 (10) :e0140131.|[4]Mathieu V, et al. Combining Anti-Human VEGF with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. Neoplasia. 2008 Dec;10 (12) :1383-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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