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Temozolomide

CAT: 804-HY-17364-01Size: 5 mgDry Ice: NoHazardous: No
5 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].
CAS Number
[85622-93-1]
Product Name Alternative
NSC 362856; CCRG 81045; TMZ
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H340, H350, H360
Target
Apoptosis; Autophagy; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Temozolomide.html
Purity
99.98
Solubility
DMSO : 20.83 mg/mL (ultrasonic) |H2O : 2.86 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N2C=N1)N=NN(C)C2=O)N
Molecular Formula
C6H6N6O2
Molecular Weight
194.15
Precautions
H302, H315, H319, H335, H340, H350, H360
References & Citations
[1]Tentori L, et al. Combined treatment with temozolomide and poly (ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood. 2002 Mar 15;99 (6) :2241-4.|[2]Perazzoli G, et al. Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression. PLoS One. 2015 Oct 8;10 (10) :e0140131.|[3]Mathieu V, et al. Combining Anti-Human VEGF with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. Neoplasia. 2008 Dec;10 (12) :1383-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

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