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Temozolomide acid

CAT: 0804-HY-W018326-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W018326-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Temozolomide acid is a carboxylic acid derivative of Temozolomide with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer[1].
CAS Number
113942-30-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/temozolomide-acid.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1N=NC2=C(N=CN2C1=O)C(O)=O
Molecular Formula
C6H5N5O3
Molecular Weight
195.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Helal DO, et al. A natural protein based platform for the delivery of Temozolomide acid to glioma cells. Eur J Pharm Biopharm. 2021 Dec;169:297-308.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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