Products for Research Use Only
RegisterLogin

Saquinavir

CAT: 0804-HY-17007-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-17007-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2][3].
CAS Number
127779-20-8
Product Name Alternative
Ro 31-8959
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Calcium Channel; HIV; HIV Protease; Interleukin Related; JNK; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Saquinavir.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@@](CCCC3)([H])[C@@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4
Molecular Formula
C38H50N6O5
Molecular Weight
670.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Pettoello-Mantovani M, et al. Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues. Antimicrob Agents Chemother. 1997 Sep;41 (9) :1880-7.|[2]Waibel S, et al. Saquinavir Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2015;37 (5) :1973-82.|[3]Yu Z, et al. Saquinavir Ameliorates Liver Warm Ischemia-Reperfusion-Induced Lung Injury via HMGB-1- and P38/JNK-Mediated TLR-4-Dependent Signaling Pathways. Mediators Inflamm. 2017;2017:7083528.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Antimicrob Agents Chemother. 2020 Aug 20;64 (9) :e00872-20.|Antiviral Res. 2022 Dec:208:105463.|Biochem Biophys Res Commun. 2025 May 16:771:152040.|Chem Eng J. 2025 Sep 15.|Exp Cell Res. 2019 Oct 1;383 (1) :111488.|Int J Antimicrob Agents. 2019 Dec;54 (6) :814-819.|J Med Chem. 2021 Mar 11;64 (5) :2725-2738.|J Pharm Sci. 2017 Sep;106 (9) :2839-2846.|J Virol. 2025 Sep 30:e0096825.|Nat Commun. 2020 Sep 4;11 (1) :4417.|Nat Commun. 2025 Feb 28;16 (1) :2078.|Northwestern University. 2025.|Phytomedicine. 2019 Mar 15:56:175-182.|Signal Transduct Target Ther. 2021 May 29;6 (1) :212.|University of Colorado Denver. 2024.|bioRxiv. 2020 Apr.

Alternative Products

CatalogName
A3790-50Saquinavir
A3791-25Saquinavir mesylate
CS-O-06952Saquinavir-d6
S0097-32Saquinavir, Mesylate
A11378-200Saquinavir 200mg
A11378-100Saquinavir 100mg

Popular Products