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Caspofungin-d4

CAT: 0804-HY-17006ASSize: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-17006ASSize:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caspofungin-d4 (MK-0991-d4; L-743872-d4) is a deuterium labeled Caspofungin. Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β- (l,3) -D-glucan[1][2][3].
CAS Number
1131958-73-0
Product Name Alternative
MK-0991-d4; L-743872-d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Fungal; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@]([C@H](CC2)O)([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@](C(N3[C@](C[C@H](C3)O)([H])C(N[C@@](C(N[C@@]1([H])[C@H](O)CCN)=O)([H])[C@H](O)[C@H](C4=CC=C(C=C4)O)O)=O)=O)([H])[C@H](O)C)=O)NC(CCCCCCCCC(C)CC(C)CC)=O)O)NC([2H])([2H])C([2H])([2H])N)=O
Molecular Formula
C52H84D4N10O15
Molecular Weight
1097.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55 (7) :3491-7.|[3]Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51 (11) :5796-803.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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