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Colchicine-d6

CAT: 0804-HY-16569SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16569SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) [4].
CAS Number
[1217651-73-4]
UNSPSC
12352005
Hazard Statement
H300, H340
Target
Apoptosis; Autophagy; Isotope-Labeled Compounds; Microtubule/Tubulin; NOD-like Receptor (NLR)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Others
Field of Research
Cancer
Purity
99.41
Solubility
10 mM in DMSO
Smiles
COC1=C(C(OC)=CC2=C1C(C([C@H](CC2)NC(C([2H])([2H])[2H])=O)=CC3=O)=CC=C3OC([2H])([2H])[2H])OC
Molecular Formula
C22H19D6NO6
Molecular Weight
405.47
Precautions
H300, H340
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218 (1) :189-200.|[3]Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51 (3) :377-401|[4]Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587.|[5]Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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