Colchicine-d6

• UNSPSC Description:

  Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

• Target Antigen:

  Apoptosis; Autophagy; Isotope-Labeled Compounds; Microtubule/Tubulin; NOD-like Receptor (NLR)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Cytoskeleton;Immunology/Inflammation;Others

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C(OC)=CC2=C1C(C([C@H](CC2)NC(C([2H])([2H])[2H])=O)=CC3=O)=CC=C3OC([2H])([2H])[2H])OC

• Molecular Weight:

  405.47

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200.|[3]Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51(3):377-401|[4]Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587.|[5]Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1217651-73-4