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Budesonide-d6

CAT: 0804-HY-W742981Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W742981Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Budesonide-d6 is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3][4].
CAS Number
1134189-63-1
UNSPSC
12352005
Target
ADC Payload; Glucocorticoid Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C([2H])=C[C@]2(C(C([2H])(C[C@@]3([C@@]2([C@@H](C[C@]4([C@@]3(C[C@H]5OC(O[C@]54C(C([2H])(O)[2H])=O)CCC)[H])C)O)[H])[H])[2H])=C1[2H])C
Molecular Formula
C25H28D6O6
Molecular Weight
436.57
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151 (3) :397-406.|[3]Liang Dong, et al. Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice. J Immunol Res. 2019 Feb 27;2019:7264383.|[4]Michael A Pereira, et al. Modulation by Budesonide of DNA Methylation and mRNA Expression in Mouse Lung Tumors. Int J Cancer. 2007 Mar 1;120 (5) :1150-3.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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