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Colchicine (Standard)

CAT: 0804-HY-16569R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16569R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) . Colchicine prevents non-steroidal anti-inflammatory drug (NSAID) -induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research[1][2][3][4][5].
CAS Number
64-86-8
UNSPSC
12352005
Hazard Statement
H300, H340
Target
Apoptosis; Autophagy; Microtubule/Tubulin; NOD-like Receptor (NLR) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/colchicine-standard.html
Purity
99.93
Smiles
CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
Molecular Formula
C22H25NO6
Molecular Weight
399.44
Precautions
H300, H340
References & Citations
[1]Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218 (1) :189-200.|[2]Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51 (3) :377-401|[3]Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587.|[4]Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143.|[5]Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030. |[6]Sami H Hammadi, et al. Effect of sacubitril/valsartan on cognitive impairment in colchicine-induced Alzheimer's model in rats. Fundam Clin Pharmacol. 2023 Apr;37 (2) :275-286.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

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