Myosin-IN-1

Myosin-IN-1

• CAS Number: 849011-39-8
• UNSPSC Description: Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1].
• Target Antigen: Myosin
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/myosin-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(N=CN1NC(NC(C)C)=S)SC(CC)=C2
• Molecular Weight: 296.41
• References & Citations: [1]Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14(1):7692.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported