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Myosin-IN-1

CAT: 0804-HY-163120Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163120Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1].
CAS Number
849011-39-8
UNSPSC
12352005
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/myosin-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N=CN1NC(NC(C)C)=S)SC(CC)=C2
Molecular Formula
C12H16N4OS2
Molecular Weight
296.41
References & Citations
[1]Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14 (1) :7692.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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