Myosin-IN-1

• UNSPSC Description:

  Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1].

• Target Antigen:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/myosin-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N=CN1NC(NC(C)C)=S)SC(CC)=C2

• Molecular Weight:

  296.41

• References & Citations:

  [1]Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14(1):7692.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  849011-39-8