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FXR antagonist 3

CAT: 0804-HY-163072Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163072Size:1 Each
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Description
FXR antagonist 3 (V02-8) is an intestine-specific farnesoid X receptor (FXR) antagonist, with an IC50 of 0.89 μM[1].
CAS Number
3024652-96-5
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fxr-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)C1=CC=C(CNC(CC2=CC=C(N(CC3=CC=CC(C)=C3)C(C4CCCC4)=O)C=C2)=O)C=C1
Molecular Formula
C32H36N2O4
Molecular Weight
512.64
References & Citations
[1]Cong Chen, et al. Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis. Eur J Med Chem. 2023 Nov 27:264:115992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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