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Aromatase-IN-3

CAT: 0804-HY-162105Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162105Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aromatase-IN-3 (compound 7d) is an aromatase inhibitor with an IC50 of 54 nM. Through suppressing the conversion of androstenedione to oestrogen caused by aromatase, Aromatase-IN-3 exerts an appreciable tumor growth inhibitory activities against breast cancer cell lines, suggesting its usage for ER+ cancer research[1].
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/aromatase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C(OCC)=O)C1=CN(CCCCCNC2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=CC=C4)\C)C=C2)C5=C1C=CC=C5
Molecular Formula
C38H38N2O3
Molecular Weight
570.72
References & Citations
[1]Rani S, et al. Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer. Eur J Med Chem. 2023 Dec 31;265:116111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1

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