DDR1-IN-8

• CAS Number:

  3038810-92-0

• UNSPSC Description:

  DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC50 values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity[1].

• Target Antigen:

  Discoidin Domain Receptor

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ddr1-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC1=CN(CC(N2CCN(CC2)C)=O)C3=C1C=C(F)C=C3)NC4=CC=C(C=C4F)F

• Molecular Weight:

  459.46

• References & Citations:

  [1]Shangke Liu, et al. Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis. Eur J Med Chem. 2024 Feb 5:265:116100.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported