DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride

• CAS Number: 1780303-76-5
• UNSPSC Description: DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].
• Target Antigen: Discoidin Domain Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ddr1-in-1-dihydrochloride.html
• Solubility: 10 mM in H2O
• Smiles: CC1=C(C=C(C=C1)NC(C2=CC=C(C(C(F)(F)F)=C2)CN3CCN(CC3)CC)=O)OC4=CC(C5)=C(C=C4)NC5=O.Cl.Cl
• Molecular Weight: 625.51
• References & Citations: [1]Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported