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VEGFR-IN-4

CAT: 0804-HY-162099Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162099Size:1 Each
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Description
VEGFR-IN-4 (Compound 6e) is an epidermal growth factor receptor (EGFR) inhibitor. VEGFR-IN-4 has potent antiproliferative activity with an IC50 value of 24.6nM against HCC827 cells[1].
CAS Number
3000483-29-1
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-in-4.html
Solubility
10 mM in DMSO
Smiles
ClC1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1NC4=C(C(NO)=O)SC=C4
Molecular Formula
C19H19ClN6O3S
Molecular Weight
446.91
References & Citations
[1]Zuo Y, et al. Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation. Eur J Med Chem. 2023 Dec 29;265:116106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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