TIE-2/VEGFR-2 kinase-IN-4

• UNSPSC Description:

  TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis[1].

• Target Antigen:

  Tie; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C=C2)OC3=CC4=C(N=C(N4)NC(C5=CC=CO5)=O)C=C3

• Molecular Weight:

  539.44

• References & Citations:

  [1]Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  433224-29-4