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EGFR-IN-185

CAT: 0804-HY-179143Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179143Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-185 is a  EGFR  inhibitor. EGFR-IN-185 exhibits potent activity against non-small cell lung cancer (NSCLC) cells harboring EGFR mutations.  EGFR-IN-185 inhibits colony formation and migration,   induces G0/G1 arrest, and promots apoptosis, which are associated with the suppression of EGFR and AKT phosphorylation.  EGFR-IN-185 can be used for the research of    NSCLC[1].
UNSPSC
12352005
Target
Akt; Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=CC(OCC3=CC=C(C4=CC=CC=C4)C=C3)=CC=C2NC5=C(C=C(F)C=C5)N1CCN(C)C
Molecular Formula
C30H28FN3O2
Molecular Weight
481.56
References & Citations
[1]Jin C, et al. Design, synthesis and structure-activity relationship analysis of dibenzodiazepinone derivatives against Osimertinib resistant NSCLC. RSC Med Chem. Published online October 16, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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