EGFR/microtubule-IN-1

• UNSPSC Description:

  EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis[1].

• Target Antigen:

  Apoptosis; EGFR; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-microtubule-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC(NC1=C(OC)C=C(N=CN=C2NC3=CC=C(Br)C=C3)C2=C1)=O)C4=CC=CC=C4

• Molecular Weight:

  492.32

• References & Citations:

  [1]Liu Y, et al. Design of balanced dual-target inhibitors of EGFR and microtubule. Bioorg Chem. 2024 Feb;143:107087.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1970269-96-5